Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor
نویسندگان
چکیده
منابع مشابه
Combined therapy with mutant-selective EGFR inhibitor and Met kinase inhibitor for overcoming erlotinib resistance in EGFR-mutant lung cancer.
Although the EGF receptor tyrosine kinase inhibitors (EGFR-TKI) erlotinib and gefitinib have shown dramatic effects against EGFR mutant lung cancer, patients become resistant by various mechanisms, including gatekeeper EGFR-T790M mutation, Met amplification, and HGF overexpression, thereafter relapsing. Thus, it is urgent to develop novel agents to overcome EGFR-TKI resistance. We have tested t...
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ژورنال
عنوان ژورنال: Cancer Discovery
سال: 2019
ISSN: 2159-8274,2159-8290
DOI: 10.1158/2159-8290.cd-18-0903